Fluent APIs use setters that return objects instead of void. Normally, Spring won't be able to use classes that implement a fluent API because the setter method won't be found. However, I have learned that it is possible to write a BeanInfo class which helps the Java reflection system. Here is a simple example: 
package com.codebits;

public class PersonBeanInfo extends SimpleBeanInfo {

    public BeanDescriptor getBeanDescriptor() {
        return new BeanDescriptor(beanClass);
    }

    private final static Class beanClass = Person.class;

    public PropertyDescriptor[] getPropertyDescriptors() {
        try {

            PropertyDescriptor name =
              new PropertyDescriptor("name", beanClass);

            PropertyDescriptor rv[] = { name };

            return rv;
        } catch (IntrospectionException e) {
            throw new Error(e.toString());
        }
    }
}

which provides guildance for this bean: 

package com.codebits;

public class Person {

    private String name = null;

    public String getName() { return this.name; }

    public Person setName(String _name) {
        this.name = _name;
        return this;
    }

    public Person() { super(); }
}